An Example of a Drug That Causes Toxicity Through the Formation of a Chemically Reactive Intermediate Mechanisms of Adverse Drug Reactions Pharmacovigilance Inhibition of thrombospondin 1 reduces glutathione activity and worsens acute liver injury during acetaminophen hepatotoxicity in mice ScienceDirect A study published in Gastroenterology describes a new mitochondrial mediator in the hepatotoxicity induced by paracetamol. Institute of Biomedical Research of Barcelona Busting the myth of methotrexate chronic hepatotoxicity Nature Reviews Rheumatology Necrostatin 1 protects against reactive oxygen species (ROS) induced hepatotoxicity in acetaminophen induced acute liver failure ScienceDirect