DIHEXA Learning from tragedy: safety and dosing in first in human trials Pharmaceutical Technology Dihexa (also known as PNB 0408) is an experimental small molecule derived from angiotensin IV. It was engineered to cross the bloodbrain barrier and has shown synaptogenic effects in preclinical models. The often quoted Dihexa shows neurotrophic activity exceeding BDNF in preclinical studies Alpha BioMed posted on the topic LinkedIn Stem cell, Granulocyte Colony Stimulating Factor and or Dihexa to promote limb function recovery in a rat sciatic nerve damage repair model: Experimental animal studies ScienceDirect