Is Melanotan II (Afamelanotide) nasal spray safe to use for tanning? You Should Avoid Using Nasal Tanning Sprays I was addicted to illegal nasal tanning sprays I loved the confidence my 'glow' gave me, but it had scary side effects Your body already makes a hormone that tells your skin to tan. Melanotan 2 is a synthetic peptide engineered to mimic that hormone but in a version that's more potent and Avoid nasal tanning sprays or nasal tanners entirely. These products promise an all over tan without sun exposure but they are unregulated, can be unsafe, and contain potentially risky substances like Melanotan 2.