A Possible Antidote for Tylenol (Paracetamol) Overdose American Council on Science and Health Tylenol's Impact on Glutathione and Liver Damage Acetaminophen induces liver injury and depletes glutathione in mice brain: Prevention by Moringa oleifera extract ScienceDirect Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. Acetaminophen Pathway (therapeutic doses), Pharmacokinetics