Department of Genetic Engineering @ SRM University: Genetic Awareness Program on Glucose 6 Phosphate Dehydrogenase Deficiency In RBCs, NADPH are produced exclusively via HMP shunt by the action of G6PD and are responsible to maintain membrane integrity preventing premature destruction. That is why G6PD deficient RBCs are Glucose 6 phosphate dehydrogenase (G6PD) deficiency: Video, Causes, & Meaning Osmosis G6PD Deficiency Causes Haemolytic Anaemia Glucose 6 phosphate dehydrogenase is an enzyme in the hexose monophosphate shunt that synthesizes NADPH. The NADPH is used to convert oxidized glutathione (GSSG) to reduced glutathione ( Treatment strategies for glucose 6 phosphate dehydrogenase deficiency: past and future perspectives: Trends in Pharmacological Sciences