Glutathione Depletion and Stalwart Anticancer Activity of Metallotherapeutics Inducing Programmed Cell Death: Opening a New Window for Cancer Therapy ACS Omega Summary. Depletion of glutathione (GSH) and increased ROS production Download Scientific Diagram Depletion of hepatic glutathione and selective protein oxidation and inhibition of lipogenesis What is glutathione? Know as the most important antioxidant in the body, glutathione is an essential antioxidant manufactured in all cells, but primarily in the liver. It is essential because it Deubiquitinases Maintain Protein Homeostasis and Survival of Cancer Cells upon Glutathione Depletion: Cell Metabolism