Acetaminophen: Is Too Much of a Good Thing Too Much? Compendium of Continuing Education in Dentistry Desacetyl Acetaminophen Glutathione CAS 129762 76 1 SCBT Santa Cruz Biotechnology Nini Munoz , PhD. Since the administration claimed Tylenol as a cause of autism, we've seen a number of alternative and 'integrative' practitioners talking Instagram Myth busting, Acetaminophen version. "Avoid Acetaminophen (Tylenol) because it causes glutathione depletion". Truth?? As a pediatrician and ER doctor and as moms we're often asked about this. And we understand why: GSH reduces NAPQI, the metabolite responsible for hepatotoxicity in acetaminophen toxicity. Toxic doses increase oxidation into NAPQI, overwhelming glutathione. How does ethanol interfere with acetaminophen metabolism? Image: https: t.co 6EY9dIwLXY