Methylation cycle hypothesis MEpedia HOTAIR interacts with PRC2 complex regulating the regional preadipocyte transcriptome and human fat distribution: Cell Reports Under high oxidative stress, the body prioritizes glutathione production over methylation. Protect cells, DNA, and lipids first before building and detoxifying. #KalishInstitute #FunctionalMedicine Do you suffer with fatigue, brain fog, mood swings, or trouble detoxing? These could be signs of an MTHFR gene mutation, which affects methylationa key process for energy, detoxification, brain function, and Your blood tests are normal. Your sleep is adequate. You're still exhausted. This is the most common presentation I see in clinic and the answer is almost never found on a